Physical interaction of STAT1 isoforms with TGF-β receptors leads to functional crosstalk between two signaling pathways in epithelial ovarian cancer

Table 1 Association of STAT1 Expression with Clinicopathological Features of Patients with Epithelial-Type Ovarian Tumors

Clinicopathological features		Age	pSTAT1-Y701			pSTAT1-S727			STAT1
Clinicopathological features	n	M (Md)	+ (%)	- (%)	P-value	+ (%)	- (%)	P-value	+ (%)	- (%)	P-value
Age at diagnosis					0.429			0.579			0.236
≤ 45	25	39 (33)	6 (24)	19 (76)		9 (36)	16 (64)		8 (28)	17 (72)
> 45	48	66 (53)	14 (29)	34 (71)		17 (35)	31 (65)		21 (41)	27 (59)
Histological type of tumor					0.287^a			0.455^b			0.066^c
Serous					0.065^d			0.747^e			0.173^f
Benign	4	42 (42)	1 (25)	3 (75)		2 (50)	2 (50)		0 (0)	4 (100)
Borderline	5	38 (34)	4 (80)	1 (20)		3 (60)	2 (40)		2 (40)	3 (60)
Malignant	27	48 (50)	7 (26)	20 (74)		11 (41)	16 (59)		14 (52)	13 (48)
Mucinous					0.333^g			0.706^h			0.333ⁱ
Benign	8	35 (32)	1 (13)	7 (87)		2 (25)	6 (75)		1 (13)	7 (87)
Borderline	2	37 (37)	1 (50)	1 (50)		1 (50)	1 (50)		1 (50)	1 (50)
Malignant	3	55 (63)	0 (0)	3 (100)		0 (0)	3 (100)		0 (0)	3 (100)
Endometrioid
Malignant	9	51 (53)	2 (22)	7 (78)		4 (44)	5 (56)		3 (33)	6 (67)
Transitional cell
Malignant	5	49 (51)	3 (60)	2 (40)		1 (20)	4 (80)		4 (80)	1 (20)
LN metastasis					0.487			0.230			0.352
Yes	10	52 (54)	2 (20)	8 (80)		2 (20)	8 (80.0)		5 (50)	5 (50)
No	63	45 (48)	17 (27)	46 (73)		24 (38)	39 (62)		24 (38)	39 (62)
FIGO stage					0.434^j			0.590^k			0.156^l
I	24	50 (52)	4 (17)	20 (83)		8 (33)	16 (67)		8 (32)	16 (68)
II	10	50 (51)	4 (40)	6 (60)		5 (50)	5 (50)		6 (60)	4 (40)
III	9	48 (50)	3 (33)	6 (67)		2 (22)	7 (78)		6 (67)	3 (33)
IV	1	38 (38)	0 (0)	1 (100)		0 (0)	1 (100)		0 (0)	1 (100)
Grade (serous)					0.072			0.274			0.031
Low-grade	29	48 (50)	5 (17)	24 (83)		10 (35)	19 (65)		13 (45)	16 (55)
High-grade	5	52 (52)	3 (60)	2 (40)		3 (60)	2 (40)		5 (100)	0 (0)

The expression of pSTAT1-Y701, pSTAT1-S727, and STAT1 in tissue microarray was detected by immunohistochemistry. For comparison of STAT1 protein expression associated with age, histological type, lymph node metastasis, FIGO stage and grade, Fisher’s exact test was applied. LN, lymph node; n, number of cases; M, mean; Md, median; −, negative expression; +, positive expression
^a,b,c Multiple comparisons of the histological types (serous, mucinous, endometrioid, and transitional cell tumors)
^d,e,fMultiple comparisons of serous tumors (benign, borderline, and malignant tumors)
^g,h,iMultiple comparisons of mucinous tumors (benign, borderline, and malignant tumors)
^j,k,lMultiple comparisons of the stages

ISSN: 1756-9966