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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: SOX30 is a key regulator of desmosomal gene suppressing tumor growth and metastasis in lung adenocarcinoma

Fig. 4

Desmosomal gene silencing diminished the effect of SOX30 overexpression on proliferation, migration and invasion of A549 and LTEP-a-2 cells. a SOX30, DSP, JUP and DSC3 expression were confirmed by WB in A549 and LTEP-a-2 cells. b MTS assays were performed to analyze cell proliferation of A549 and LTEP-a-2 cells cotransfected with desmosomal gene miRNA and SOX30 expression vector. *P < 0.05; **P < 0.01. c The effect of increasing SOX30 expression with decreasing desmosomal gene expression on cell growth was further confirmed by colony formation assay in A549 and LTEP-a-2 cells. d Assessment of the effects of the expression of SOX30 and desmosomal gene, respectively, on cell migration and invasion in A549 and LTEP-a-2 cells

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