Fig. 6

SOX30 inhibits Wnt and ERK signaling by accelerating the expression of desmosomal gene. a The protein expression of SOX30, DSP, JUP, CCND1 and MMP7 were detected in A549-SOX30 cells and subcutaneous tumors of mice. b A549 cells with SOX30 or vector control stable expression were co-transfected with luciferase reporter constructs (TOPFlash or FOPFlash, respectively) and Renilla luciferase constructs (normalizing transfection control). The reporter activity was measured 24 h after transfection. Error bars represent the s.d. of three independent experiments. ** SOX30 vs vector control, Student’s t-test, P < 0.01. c The protein expression of SOX30, DSC3, ERK1/2 and p-ERK1/2 were detected in A549-SOX30 cells and subcutaneous tumors of mice