Fig. 1From: Up-regulation of FGF15/19 signaling promotes hepatocellular carcinoma in the background of fatty livera The HCC tumor growth pattern represented as the regression of HCC nodule length and HCC nodule numbers in individual HCC mouse. b Tumor volume from 4 groups at month 6 and month 10. c Representative histological changes from all 4 experimental groups at month 10. Histological changes of NASH-HCC in DEN+HFD mice were identified in tissue sections by H&E staining. Lipid drops were identified in tissue sections by Oil red O staining. NASH was found typically affecting the liver parenchyma with macrovesicular changes presented in a predominantly perivenular distribution. In addition to fatty change, many hepatocytes in acinar showed ballooning and contain Mallory’s hyaline, and mixed infiltrate of inflammatory cells. UT: untreated; CD: control diet; HFD: high fat diet; DEN: N-nitrosodiethylamine. d Positive F4/80 cells and mRNA expressions (IL-6, TNF-α and TGF-β1) in the liver tissues from 4 groups at month 6 and month 10. *, P < 0.05 vs UT + CDBack to article page