Skip to main content
Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Emerging role of lipid metabolism alterations in Cancer stem cells

Fig. 2

NANOG mediated metabolic reprogramming contributes to CSCs self-renewal and chemoresistance. NANOG binding on FAO genes(Acadvl, Echs1, and Acads) promoters stimulates it’s transcription but exerts opposite effect on OXPHOS genes(Cox6a2 and Cox15) transcription, leading to metabolic switch from OXPHOS to FAO and less ROS production in CSCs/TICs. NANOG also promotes lipid desaturation via up-regulating SCD1 expression. OXPHOS, oxidative phosphorylation; FAO, fatty acid oxidation

Back to article page