Fig. 4From: Emerging role of lipid metabolism alterations in Cancer stem cellsInteraction between oncogenic signaling and lipid desaturation in CSCs. Oncogenic activation of K-RAS, PI3K/AKT/mTOR signaling stimulates de novo lipogenesis via upregulation of SREBP1. Increase of SCD1 expression and lipid desaturation by NANOG or oncogenic signaling in CSCs or TICs reciprocally amplify NF-κB, Wnt/β-catenin, and Yap activation. Activation of JAK/STAT3 promotes CPT1B expression and activates the FAO pathway, which in turn contributes to Src oncoprotein activation. SREBP1, sterol regulatory element-binding protein-1Back to article page