Fig. 7

Lycorine’s inhibition on GBM growth is dependent on EGFR in vivo. a Photos of tumor-bearing nude mice and their xenografts at indicated days of U251 shControl and shEGFR after inoculation. White triangle indicates the tumors that grow subcutaneously in mice right backs. b The growth curve of U251 shControl and shEGFR tumor volume after their inoculation from day 0 to day 32. c Representative images of tumor tissue in control, shEGFR, shControl+Lycorine 20 mg/kg/day and shEGFR+Lycorine 20 mg/kg/day groups. d The tumor volume of 4 groups was shown through growth curve (n = 4, **, P < 0.01). e The statistic result of tumor weight in control, shEGFR, shControl+Lycorine 20 mg/kg/day and shEGFR+Lycorine 20 mg/kg/day groups. The means and 95% confidence intervals (error bars) were presented (n = 4, **, P < 0.01). f Dissected tumor tissues were extracted protein and subjected to Western blotting analysis and the expression of EGFR was detected in 4 groups