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Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII

Fig. 9

Stress-regulated alternative TrkAIII splicing promotes neural- and neural-crest-related tumour progression. Schematic representation equating the tumour suppressing TrkA effects (differentiation, growth arrest, apoptosis and inhibition of angiogenesis) to the oncogenic TrkAIII effects (proliferation, staminality, stress resistance, survival, angiogenesis, genetic instability and the Warburg effect) resulting from D4 domain-deletion, receptor re- intracellular localisation, PIP3K/Akt/NF-κB, centrosome amplification and ER-stress induced translocation to and activation within the mitochondria

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