Fig. 5

The performance of the metabolic and EMT subtype CTCs in the diagnosis of tumor metastasis. a Glucose metabolic classification of CTCs in non-metastatic and metastatic patients. b EMT phenotypes of CTCs in non-metastatic and metastatic patients. c–d Simulated ROC curves of the CTCs parameters for discriminating the metastatic PCa patients from the non-metastatic patients, including E-CTCs, H-CTCs, and M-CTCs (c), GM⁺CTCs and total CTCs (d). e Simulated ROC curves of the combined bigeminal (i and ii) or trigeminal (iii) markers of GM⁺CTCs and H⁻CTCs for discriminating the metastatic PCa patients from the non-metastatic patients