Fig. 5

PTEN lipid phosphatase inactivation activates the PI3K/Akt pathway through a mechanism dependent on the Hippo pathway. a, b The expression of key proteins in the PI3K/Akt pathway was detected in stable cell lines. c, d Association between p-Akt (Ser473) and p-PTEN or nuclear YAP in GC specimens. e, f The expression of Akt and p-Akt was detected after treatment with 0, 0.5, 1, and 5 μM VP