Table 2 Correlation of YAP protein expression with clinicopathologic features in GC patients
Variables | YAP expression | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
All cases (n = 90) | Low expression (n = 37) | High expression (n = 53) | p value | High nuclear expression (n = 25) | Low nuclear expression (n = 65) | p value | High cytoplasmic expression (n = 21) | Low cytoplasmic expression (n = 69) | p value | |
Sex | ||||||||||
 Male | 53 | 22 | 31 | 0.927 | 15 | 38 | 0.894 | 13 | 40 | 0.748 |
 Female | 37 | 15 | 22 | 10 | 27 | 8 | 29 | |||
Age (years) | ||||||||||
  ≥ 63 | 46 | 19 | 27 | 0.970 | 12 | 34 | 0.714 | 11 | 35 | 0.894 |
  < 63 | 44 | 18 | 26 | 13 | 31 | 10 | 34 | |||
Tumor size (cm) | ||||||||||
  ≥ 5.5 | 42 | 12 | 30 | 0.024 | 16 | 26 | 0.041 | 11 | 31 | 0.549 |
  < 5.5 | 48 | 25 | 23 | 9 | 39 | 10 | 38 | |||
Location | ||||||||||
 Upper 1/3 | 10 | 3 | 7 | 0.424 | 3 | 7 | 0.492 | 3 | 7 | 0.518 |
 Middle | 27 | 11 | 16 | 10 | 17 | 4 | 23 | |||
 Low 1/3 | 51 | 22 | 29 | 12 | 39 | 13 | 38 | |||
 Remnant | 2 | 1 | 1 | 0 | 2 | 1 | 1 | |||
T classification | ||||||||||
 T1 | 3 | 3 | 0 | 0.040 | 0 | 3 | 0.003 | 0 | 3 | 0.708 |
 T2 | 11 | 5 | 6 | 3 | 8 | 2 | 9 | |||
 T3 | 53 | 24 | 29 | 9 | 44 | 14 | 39 | |||
 T4 | 23 | 5 | 18 | 13 | 10 | 5 | 18 | |||
N classification | ||||||||||
 N0 | 22 | 17 | 5 | 0.000 | 1 | 21 | 0.005 | 4 | 18 | 0.511 |
 N1/N2/N3 | 68 | 20 | 48 | 24 | 44 | 17 | 51 | |||
Clinical stage | ||||||||||
 I/II | 36 | 27 | 9 | 0.000 | 2 | 34 | 0.000 | 6 | 30 | 0.222 |
 III/IV | 54 | 10 | 44 | 23 | 31 | 15 | 39 | |||