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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side

Fig. 1

General landscape of redox singnalling. Here we present the main molecular targets of ROS described to date: classical signalling proteins, such as kinases, phosphatases or small GTPases; transcription factors and epigenetic modullators; and calcium fluxes, with which there exists a complex cross-talk (see text). Red arrows mean inhibition of the target or process; green arrows mean activation; blue arrow with ‘~’ symbol means that both activation and inhibition can be achieved depending on the specific target. Dotted lines indicate propose or not empirically demonstrated relationship

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