Fig. 2
From: Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side
Redox-based treatment of haematological malignancies. The diagram shows three different approaches relying on ROS modulation of leukaemic cells: increasing ROS either upon stimulation of their cellular sources or inhibition of the antioxidant systems, in order to exceed the amount compatible with life, and decreasing the ROS, mainly by inhibition of cellular sources, thereby depleting the proliferative advantage that these products provide to the cancer cell. Some examples of drugs or plausible therapeutic strategies and their cognate cellular targets illustrate the three approaches described (see text for details). Dotted arrows with question marks indicate plausible but not completely established mechanisms of action