Fig. 5

Polarization of immune response following CY, shIL10–3 LVs and BMDC/TAg treatment. a Representative dotplots presenting changes in the Tbet expression and IFN-γ production in CD4⁺ and CD8⁺ T lymphocytes between groups treated with shIL10–3 LVs; b The percentage of CD4⁺Tbet⁺IFN-γ⁺ cells; c The Th1 to Treg ratio; d The percentage of CD8⁺Tbet⁺IFN-γ⁺ cells. To calculate the mean ± SD at least 5 mice per group were analyzed. The differences between the groups were estimated using nonparametric Kruskal-Wallis test followed by Dunn’s multi comparison test (* p < 0.05, ** p < 0.01, *** p < 0.001)