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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Prolonged inhibition of class I PI3K promotes liver cancer stem cell expansion by augmenting SGK3/GSK-3β/β-catenin signalling

Fig. 7

Prolonged treatment of HCC cells with PI3K inhibitors stimulates the β-catenin signalling pathway via activation of SGK3. a The expression of β-catenin in MHCC97H cells treated with 2.5 μM of ZSTK474 for 0 to 5 days was detected by western blot. b Western blot analysis of the effect of SGK3 knockdown by siRNA on the induced overexpression of β-catenin by treatment with 2.5 μM ZSTK474. c Schematic representation of prolonged treatment of HCC cells with class I PI3K inhibitors promotes the expansion of liver CSCs, partially by activating the SGK3/GSK3β/β-catenin signalling pathway. All experiments were performed in triplicate, and the results are shown as mean ± standard deviation. *P < 0.05

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