Fig. 4

Gene ontology analysis of differentially expressed genes in U251 cells treated with AKBA for 48 h compared to control cells. a Volcano plot of differential expression results (up-regulated genes are in red; down-regulated genes are in blue; fold change > 3, FDR < 0.01). b Heatmap of differentially expressed genes. c Top ten enriched biological processes. d Top ten enriched cell components. e Top ten enriched molecular functions. (count ≥3, fold of change ≥3, EASE score < 0.01)