Fig. 5

Enrichment of KEGG pathways and protein-protein interactions. a KEGG pathway enrichment of differentially expressed genes (fold change ≥3 and FDR < 0.01). b Network of KEGG pathways. c Gene-gene interactions. The network was visualized using Cytoscape 3.6.0. Colors of the inside nodes indicate the expression levels of quantified mRNAs (up-regulated genes are in red; down-regulated genes are in blue). Size of the nodes indicates the edge counts of the gene. The gray density of the edges defines the gene-gene interaction score identified in the STRING public database