Fig. 8From: Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylationA model depicting the proposed mechanism for Ajuba-mediated effects on HCC cell growth and its regulation by Hakai. A working model illustrating that Ajuba-knockdown induced β-catenin translocation and activity as well as YAP signaling to promote HCC cells growth. In addition, Hakai promoted Ajuba degradation via neddylationBack to article page