Fig. 8

miR-98-5p impairs tumorigenicity and metastasis in vivo. a Photograph of tumors obtained from the different groups of nude mice transfected with miR-98-5p-mimics and miR-98-5p-inhibitor, respectively. b Tumor weight was calculated. c, d Growth curve of tumor volume was calculated. e, f Representative images of the livers and its HE staining in different groups were shown (Scale bar, 100 μm). The number of liver metastatic nodules was calculated. g, h The expression levels of miR-98-5p, MAP4K4 and MAPK/ERK signaling in the subcutaneous tumors that were transfected with miR-98-5p-mimics and miR-98-5p-inhibitor were explored by miRNA qRT-PCR, qRT-PCR and western blot. *P < 0.05, **P < 0.01, ***P < 0.001. The data expressed as the mean ± SD