Fig. 4
Promotion of in vivo tumor growth by CPNE1 overexpression. a-c CPNE1 overexpression in A549 cell xenografts in nude mice (n = 6) at the experimental endpoint; tumors were dissected and photographed as shown. Tumor growth curves in mice (n = 6 in each group) inoculated with the indicated cells at the indicated days d Each tumor formed was weighed. e CPNE1 mRNA expression in tumors was detected by qRT-PCR analysis. f Hematoxylin and eosin (H&E) staining confirmed the presence of tumor cells in the indicated tumor sections. Immunohistochemical staining for CPNE1 was quantified based on staining intensity. *P < 0.05; **P < 0.01; ***P < 0.001