CPNE1 is a target of miR-335-5p and plays an important role in the pathogenesis of non-small cell lung cancer

Table 1 Clinical characteristics and levels of miR-335-5p and Copine1 mRNA expression in NSCLC tissues

Characteristics	n = 60(%)	miR-335-5p mRNA expression		p value	CPNE1 mRNA expression		p value
		high	low		high	low
		(n = 15)	(n = 45)		(n = 53)	(n = 7)
Age
≤65	41 (68%)	9	32	0.432	36	5	0.851
> 65	19 (32%)	6	13	0.432	17	2	0.851
Gender
Male	38 (63%)	10	28	0.757	34	4	0.718
Female	22 (37%)	5	17	0.757	19	3	0.718
Histology
Adenocarcinoma	33 (55%)	7	26	0.479	30	3	0.661
Squamous cell carcinoma	17 (28%)	4	13		14	3
Others	10 (17%)	4	6		9	1
Smoking status
Yes	33 (55%)	7	26	0.454	30	3	0.492
No	27 (45%)	8	19	0.454	23	4	0.492
Clinical stage
I/II	24 (40%)	4	20	0.224	21	3	0.870
III/IV	36 (60%)	11	25	0.224	32	4	0.870
Lymph node metastasis
No	24 (40%)	10	14	0.015	18	6	0.009
Yes	36 (60%)	5	31	0.015	35	1	0.009

Date are presented as the mean ± SE values. Unpaired t test was used for comparison between two groups, and the Kruskal-Wallis test was for comparison of three or more groups

ISSN: 1756-9966