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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Downregulation of miR-133a-3p promotes prostate cancer bone metastasis via activating PI3K/AKT signaling

Fig. 3

Upregulating miR-133a-3p represses bone metastasis of PC-3 cells in vivo. a Schematic model illustrating the time and route of agomir-133a-3p or scramble administration in a mouse model of bone metastasis. b Representative BLIs signal of bone metastasis of a mouse from the indicated groups of mice at 5 mins and 70 day respectively. c Representative radiographic images of bone metastases in the indicated mice (arrows indicate osteolytic lesions). d Representative H&E-stained sections of tibias from the indicated mouse. Scale bar, 500 μm (40× magnification) and 100 μm (200× magnification). e The sum of bone metastasis scores for each mouse in tumor-bearing mice inoculated with vector (n = 8) or agomir-133a-3p (n = 9) cells. f Quantification of the BLI signaling in the scramble or agomir-133a-3p groups at 5, 6, 7 and 8 weeks respectively. *P < 0.05. g Kaplan-Meier analysis of mouse bone metastasis-free survival in the scramble or agomir-133a-3p groups

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