Fig. 1

SIRT7 expression is related to OSCC progression. (a) Representative IHC staining image of OSCC without lymph node metastasis (P, n = 20) and OSCC with lymph node metastasis tissues (M, n = 20), and adjacent normal oral tissues (NC, n = 20). (b) Relative quantitative comparison of the IHC results of SIRT7 expression in tissue samples between Group P, M, NC; n = 20 each group. * P < 0.05 when compared with group NC (c) Representative results of WB analysis for SIRT7 protein expression between between Group P, M, NC, n = 5 each group. (d) Relative quantitative comparison of WB analysis mentioned above. * P < 0.05 when compared with group NC (e) The results of western blot analysis for SIRT7 protein expression between metastatic lymph nodes tissuess (ML) than the matched primary lymph node (NL). (f) Relative quantitative comparison of WB analysis mentioned above. * P < 0.05 when compared with group NL; (g) The results of western blot analysis for SIRT7 protein expression between HOK and OSCC cell lines. (h) Relative quantitative comparison of WB analysis of cell lines. * P < 0.05 when compared with the results of HOK cell line.(i) The results of bioinformatics analysis based on the ProgeneV2 prognostic database (http://www.abren.net/PrognoScan/). (j) Representative results of WB analysis for SIRT7 protein expression between between Group P, M, n = 5 each group. (k) Relative quantitative of E-Cadherin levels comparison of WB analysis of the results of P group. * P < 0.05 when compared with P group. (l) Relative quantitative of vimentin levels comparison of WB analysis of the results of P group. * P < 0.05 when compared with P group