Fig. 3

Effects of single and combined MEK and RAF inhibition in xenograft models. MiaPaCa2 cell lines were intramuscularly injected into immunodeficient athymic mice. After tumors became palpable (day 13), mice were treated with Vehicle (C), dabrafenib (D), trametinib (T) or combination (Combo) for 2 weeks. The longest perpendicular diameters of each individual tumor was measured at different time points and tumor weight was calculated. Results from one representative experiment out of two independent ones performed are shown. Asterisks indicate statistically significant differences (p ≤ 0.02 by 2-tailed Student’s t test) for the comparison between * combination- and dabrafenib-treated mice or ** combination- and trametinib-treated mice