Journal of Experimental & Clinical Cancer Research

Table 1 The correlation between the clinical characteristics of 85 patients and the expression levels of circ-IARS or linear-IARS

From: Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis

Parameters	circ-IARS			linar-IARS
	High	Low	P-value	High	Low	P-value
	(n = 42)	(n = 43)	/χ²	(n = 42)	(n = 43)	/χ²
Gender			0.529			0.750
Male	31	35	0.396	32	34	0.101
Female	11	8		10	9
Age, years			0.235			0.906
≤ 60	20	26	1.412	23	23	0.014
> 60	22	17		19	20
Tumor location			0.557			0.263
Head	32	35	0.345	31	36	1.250
Body or tail	10	8		11	7
Tumor size, cm			0.397			0.591
≤ 2	12	16	0.718	15	13	0.289
> 2	30	27		27	30
Neural invasion			0.595			0.595
Yes	17	15	0.283	17	15	0.283
No	25	28		25	28
Duodenal invasion			0.715			0.778
Yes	6	5	0.133	5	6	0.079
No	36	38		37	37
Differentiation			^a0.410			1.000
Low	11	9	2.119	10	10	0.096
Median	29	28		28	29
High	2	6		4	4
Lymphatic invasion			0.058			0.058
Yes	19	11	3.595	19	11	3.595
No	23	32		23	32
Vascular invasion			0.020			0.901
Yes	15	6	5.409	12	9	0.015
No	27	37		30	24
Liver metastasis			^a 0.011			0.481
Yes	10	2	6.432	8	4	0.496
No	32	41		34	39
TNM			0.023			0.065
I, IIa	18	29	5.195	19	28	3.396
IIb, III and IV	24	14		23	15

^aThere are at least 1 lattice theoretical frequencies less than 5, so the Fisher exact test is adopted (Monte Carlo test)
Bold value indicates that its P-value less than 0.05

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