Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis

Table 2 Univariate analyses of prognostic factors in pancreatic adenocarcinoma

Parameters	Patients, n	Median survial time	P-value	χ ²
Gender			0.016	5.770
Male	61	16
Female	18	11
Age			0.419	0.653
≤ 60	43	14
> 60	36	14
Tumor location			0.135	2.233
Head	61	16
Body, tail	18	11
Tumor size, cm			0.521	0.412
≤ 2	26	15
> 2	53	14
Neural invasion			0.590	0.29
Yes	29	14
No	50	14
Duodenal invasion			0.329	0.951
Yes	11	12
No	68	16
Differentiation			0.996	0.008
Low	18	14
Median	54	14
High	7	18
Lymphatic invasion			0.202	1.625
Yes	29	11
No	50	16
Vascular invasion			0.038	4.283
Yes	19	13
No	60	16
Liver metastasis			0.000	48.761
Yes	12	5
No	67	16
TNM			0.011	6.400
I, IIa	42	16
IIb, III and IV	37	11
circ-IARS			0.010	6.633
High	40	11
Low	39	16
linar-IARS			0.061	3.517
High	42	13
Low	37	16

ISSN: 1756-9966