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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Protein phosphatase 2A activation mechanism contributes to JS-K induced caspase-dependent apoptosis in human hepatocellular carcinoma cells

Fig. 7

Effects of FTY720 on JS-K-induced cell apoptosis and PP2A activation in SMMC7721 and HepG2 cells. a Effect of FTY720 treatment as PP2A agonist on cell apoptosis. The cells were pre-treated with FTY720 (2 μM) for 1 h, and then stimulated with JS-K (10 μM) for 24 h. The apoptosis was assessed by flow cytometry. b Effect of FTY720 treatment as PP2A agonist on the expression of apoptotic-related protein. c Effect of FTY720 treatment as PP2A agonist on the expression of PP2A-C and its substrates. The cells were pretreated with FTY720 (2 μM) for 1 h, and then stimulated with JS-K (10 μM) for 24 h. The expressions of protein were assessed by Western blotting analysis. Data are mean ± SD. n = 3 for each concentration. *P < 0.05,**P < 0.01, vs. control group, #P < 0.05, ##P < 0.01 vs. cells treated with JS-K alone

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