Fig. 2
From: Correction to: Emerging role of lipid metabolism alterations in Cancer stem cells
Interaction between oncogenic signaling and lipid desaturation in CSCs. Activation of NANOG, SREBP1 and oncogenic signaling such as Wnt/β-catenin, mTOR and NF-κB signaling stimulate lipid desaturation via induction of SCD1 expression. Increase of lipid desaturation reciprocally amplify NF-κB, Wnt/β-catenin, and Yap activation, which contribute to the self-renewal of CSCs or TICs. SREBP1, sterol regulatory element-binding protein-1