TY - JOUR AU - Torre, L. A. AU - Bray, F. AU - Siegel, R. L. AU - Ferlay, J. AU - Lortet-Tieulent, J. AU - Jemal, A. PY - 2015 DA - 2015// TI - Global cancer statistics, 2012 JO - CA Cancer J Clin VL - 65 UR - https://doi.org/10.3322/caac.21262 DO - 10.3322/caac.21262 ID - Torre2015 ER - TY - JOUR AU - Brody, H. PY - 2015 DA - 2015// TI - Colorectal cancer JO - Nature VL - 521 UR - https://doi.org/10.1038/521S1a DO - 10.1038/521S1a ID - Brody2015 ER - TY - JOUR AU - Siegel, R. L. AU - Miller, K. D. AU - Fedewa, S. A. AU - Ahnen, D. J. AU - Meester, R. G. S. AU - Barzi, A. AU - Jemal, A. PY - 2017 DA - 2017// TI - Colorectal cancer statistics, 2017 JO - CA Cancer J Clin VL - 67 UR - https://doi.org/10.3322/caac.21395 DO - 10.3322/caac.21395 ID - Siegel2017 ER - TY - JOUR AU - Liu, L. G. AU - Yan, X. B. AU - Xie, R. T. AU - Jin, Z. M. AU - Yang, Y. PY - 2017 DA - 2017// TI - Stromal expression of vimentin predicts the clinical outcome of stage II colorectal Cancer for high-risk patients JO - Med Sci Monit VL - 23 UR - https://doi.org/10.12659/MSM.904486 DO - 10.12659/MSM.904486 ID - Liu2017 ER - TY - JOUR AU - Ejaz, A. AU - Casadaban, L. AU - Maker, A. V. PY - 2017 DA - 2017// TI - Utilization and impact of adjuvant chemotherapy among patients with resected stage II colon cancer: a multi-institutional analysis JO - J Surg Res VL - 215 UR - https://doi.org/10.1016/j.jss.2017.03.017 DO - 10.1016/j.jss.2017.03.017 ID - Ejaz2017 ER - TY - JOUR AU - Aran, V. AU - Victorino, A. P. AU - Thuler, L. C. AU - Ferreira, C. G. PY - 2016 DA - 2016// TI - Colorectal Cancer: epidemiology, disease mechanisms and interventions to reduce onset and mortality JO - Clin Colorectal Cancer VL - 15 UR - https://doi.org/10.1016/j.clcc.2016.02.008 DO - 10.1016/j.clcc.2016.02.008 ID - Aran2016 ER - TY - JOUR AU - Militello, R. AU - Colombo, M. I. PY - 2013 DA - 2013// TI - Small GTPases as regulators of cell division JO - Commun Integr Biol VL - 6 UR - https://doi.org/10.4161/cib.25460 DO - 10.4161/cib.25460 ID - Militello2013 ER - TY - JOUR AU - Johnson, D. S. AU - Chen, Y. H. PY - 2012 DA - 2012// TI - Ras family of small GTPases in immunity and inflammation JO - Curr Opin Pharmacol VL - 12 UR - https://doi.org/10.1016/j.coph.2012.02.003 DO - 10.1016/j.coph.2012.02.003 ID - Johnson2012 ER - TY - STD TI - Hilbi H, Kortholt A. Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection. Small GTPases. 2017:1–7. ID - ref9 ER - TY - JOUR AU - Wu, Y. AU - Zhou, J. AU - Li, Y. AU - Zhou, Y. AU - Cui, Y. AU - Yang, G. AU - Hong, Y. PY - 2015 DA - 2015// TI - Rap1A regulates osteoblastic differentiation via the ERK and p38 mediated signaling JO - PLoS One VL - 10 UR - https://doi.org/10.1371/journal.pone.0143777 DO - 10.1371/journal.pone.0143777 ID - Wu2015 ER - TY - JOUR AU - Lu, L. AU - Wang, J. AU - Wu, Y. AU - Wan, P. AU - Yang, G. PY - 2016 DA - 2016// TI - Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling JO - Cancer Med VL - 5 UR - https://doi.org/10.1002/cam4.946 DO - 10.1002/cam4.946 ID - Lu2016 ER - TY - JOUR AU - Bailey, C. L. AU - Kelly, P. AU - Casey, P. J. PY - 2009 DA - 2009// TI - Activation of Rap1 promotes prostate cancer metastasis JO - Cancer Res VL - 69 UR - https://doi.org/10.1158/0008-5472.CAN-08-4269 DO - 10.1158/0008-5472.CAN-08-4269 ID - Bailey2009 ER - TY - JOUR AU - Wang, K. AU - Li, J. AU - Guo, H. AU - Xu, X. AU - Xiong, G. AU - Guan, X. AU - Liu, B. AU - Li, J. AU - Chen, X. AU - Yang, K. AU - Bai, Y. PY - 2012 DA - 2012// TI - MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis JO - Carcinogenesis VL - 33 UR - https://doi.org/10.1093/carcin/bgs259 DO - 10.1093/carcin/bgs259 ID - Wang2012 ER - TY - JOUR AU - Sayyah, J. AU - Bartakova, A. AU - Nogal, N. AU - Quilliam, L. A. AU - Stupack, D. G. AU - Brown, J. H. PY - 2014 DA - 2014// TI - The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth JO - J Biol Chem VL - 289 UR - https://doi.org/10.1074/jbc.M113.536227 DO - 10.1074/jbc.M113.536227 ID - Sayyah2014 ER - TY - JOUR AU - Xiang, J. AU - Bian, C. AU - Wang, H. AU - Huang, S. AU - Wu, D. PY - 2015 DA - 2015// TI - MiR-203 down-regulates Rap1A and suppresses cell proliferation, adhesion and invasion in prostate cancer JO - J Exp Clin Cancer Res VL - 34 UR - https://doi.org/10.1186/s13046-015-0125-x DO - 10.1186/s13046-015-0125-x ID - Xiang2015 ER - TY - JOUR AU - Yan, X. AU - Shan, Z. AU - Yan, L. AU - Zhu, Q. AU - Liu, L. AU - Xu, B. AU - Liu, S. AU - Jin, Z. AU - Gao, Y. PY - 2016 DA - 2016// TI - High expression of zinc-finger protein X-linked promotes tumor growth and predicts a poor outcome for stage II/III colorectal cancer patients JO - Oncotarget VL - 7 ID - Yan2016 ER - TY - JOUR AU - Wu, D. AU - Liu, L. AU - Yan, X. AU - Wang, C. AU - Wang, Y. AU - Han, K. AU - Lin, S. AU - Gan, Z. AU - Min, D. PY - 2017 DA - 2017// TI - Pleiotrophin promotes chemoresistance to doxorubicin in osteosarcoma by upregulating P-glycoprotein JO - Oncotarget VL - 8 ID - Wu2017 ER - TY - STD TI - Papke B, Der CJ. Drugging RAS: Know the enemy. Science. 2017;355:1158–63. ID - ref18 ER - TY - JOUR AU - Yan, C. AU - Theodorescu, D. PY - 2018 DA - 2018// TI - RAL GTPases: biology and potential as therapeutic targets in Cancer JO - Pharmacol Rev VL - 70 UR - https://doi.org/10.1124/pr.117.014415 DO - 10.1124/pr.117.014415 ID - Yan2018 ER - TY - JOUR AU - Vigil, D. AU - Cherfils, J. AU - Rossman, K. L. AU - Der, C. J. PY - 2010 DA - 2010// TI - Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? JO - Nat Rev Cancer VL - 10 UR - https://doi.org/10.1038/nrc2960 DO - 10.1038/nrc2960 ID - Vigil2010 ER - TY - JOUR AU - Di, J. AU - Tang, J. AU - Qian, H. AU - Franklin, D. A. AU - Deisenroth, C. AU - Itahana, Y. AU - Zheng, J. PY - 2017 DA - 2017// TI - Zhang Y. p53 upregulates PLCepsilon-IP3-ca(2+) pathway and inhibits autophagy through its target gene Rap2B JO - Oncotarget VL - 8 ID - Di2017 ER - TY - STD TI - Li Y, Li S, Huang L. Knockdown of Rap2B, a Ras superfamily protein, inhibits proliferation, migration, and invasion in cervical Cancer cells via regulating the ERK1/2 signaling pathway. Oncol Res. 2018;26:123–30. ID - ref22 ER - TY - JOUR AU - Pan, Y. AU - Zhang, Y. AU - Chen, L. AU - Liu, Y. AU - Feng, Y. AU - Yan, J. PY - 2016 DA - 2016// TI - The critical role of Rab31 in cell proliferation and apoptosis in Cancer progression JO - Mol Neurobiol VL - 53 UR - https://doi.org/10.1007/s12035-015-9378-9 DO - 10.1007/s12035-015-9378-9 ID - Pan2016 ER - TY - JOUR AU - Kotzsch, M. AU - Kirchner, T. AU - Soelch, S. AU - Schafer, S. AU - Friedrich, K. AU - Baretton, G. AU - Magdolen, V. AU - Luther, T. PY - 2017 DA - 2017// TI - Inverse association of rab31 and mucin-1 (CA15-3) antigen levels in estrogen receptor-positive (ER+) breast cancer tissues with clinicopathological parameters and patients' prognosis JO - Am J Cancer Res VL - 7 ID - Kotzsch2017 ER - TY - JOUR AU - Chen, C. H. AU - Chuang, H. C. AU - Huang, C. C. AU - Fang, F. M. AU - Huang, H. Y. AU - Tsai, H. T. AU - Su, L. J. AU - Shiu, L. Y. AU - Leu, S. AU - Chien, C. Y. PY - 2013 DA - 2013// TI - Overexpression of rap-1A indicates a poor prognosis for oral cavity squamous cell carcinoma and promotes tumor cell invasion via aurora-a modulation JO - Am J Pathol VL - 182 UR - https://doi.org/10.1016/j.ajpath.2012.10.023 DO - 10.1016/j.ajpath.2012.10.023 ID - Chen2013 ER - TY - STD TI - Mahar AL, Compton C, Halabi S, Hess KR, Weiser MR, Groome PA. Personalizing prognosis in colorectal cancer: a systematic review of the quality and nature of clinical prognostic tools for survival outcomes. J Surg Oncol. 2017;116:969–82. ID - ref26 ER - TY - JOUR AU - Punt, C. J. AU - Koopman, M. AU - Vermeulen, L. PY - 2017 DA - 2017// TI - From tumour heterogeneity to advances in precision treatment of colorectal cancer JO - Nat Rev Clin Oncol VL - 14 UR - https://doi.org/10.1038/nrclinonc.2016.171 DO - 10.1038/nrclinonc.2016.171 ID - Punt2017 ER - TY - JOUR AU - Cuyle, P. J. AU - Prenen, H. PY - 2017 DA - 2017// TI - Current and future biomarkers in the treatment of colorectal cancer JO - Acta Clin Belg VL - 72 UR - https://doi.org/10.1080/17843286.2016.1262996 DO - 10.1080/17843286.2016.1262996 ID - Cuyle2017 ER - TY - JOUR AU - Sun, Z. AU - Wang, F. AU - Zhou, Q. AU - Yang, S. AU - Sun, X. AU - Wang, G. AU - Li, Z. AU - Zhang, Z. AU - Song, J. AU - Liu, J. AU - Yuan, W. PY - 2017 DA - 2017// TI - Pre-operative to post-operative serum carcinoembryonic antigen ratio is a prognostic indicator in colorectal cancer JO - Oncotarget VL - 8 ID - Sun2017 ER - TY - STD TI - Zhan X, Sun X, Hong Y, Wang Y, Ding K. Combined Detection of Preoperative Neutrophil-to-Lymphocyte Ratio and CEA as an Independent Prognostic Factor in Nonmetastatic Patients Undergoing Colorectal Cancer Resection Is Superior to NLR or CEA Alone. Biomed Res Int. 2017;2017:3809464. ID - ref30 ER - TY - JOUR AU - Tsai, P. L. AU - Su, W. J. AU - Leung, W. H. AU - Lai, C. T. AU - Liu, C. K. PY - 2016 DA - 2016// TI - Neutrophil-lymphocyte ratio and CEA level as prognostic and predictive factors in colorectal cancer: a systematic review and meta-analysis JO - J Cancer Res Ther VL - 12 UR - https://doi.org/10.4103/0973-1482.144356 DO - 10.4103/0973-1482.144356 ID - Tsai2016 ER - TY - JOUR AU - Schmid, M. C. AU - Franco, I. AU - Kang, S. W. AU - Hirsch, E. AU - Quilliam, L. A. AU - Varner, J. A. PY - 2013 DA - 2013// TI - PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0060226 DO - 10.1371/journal.pone.0060226 ID - Schmid2013 ER - TY - JOUR AU - Bischoff, A. AU - Huck, B. AU - Keller, B. AU - Strotbek, M. AU - Schmid, S. AU - Boerries, M. AU - Busch, H. AU - Muller, D. AU - Olayioye, M. A. PY - 2014 DA - 2014// TI - miR149 functions as a tumor suppressor by controlling breast epithelial cell migration and invasion JO - Cancer Res VL - 74 UR - https://doi.org/10.1158/0008-5472.CAN-13-3319 DO - 10.1158/0008-5472.CAN-13-3319 ID - Bischoff2014 ER - TY - JOUR AU - Lim, J. A. AU - Juhnn, Y. S. PY - 2016 DA - 2016// TI - Isoproterenol increases histone deacetylase 6 expression and cell migration by inhibiting ERK signaling via PKA and Epac pathways in human lung cancer cells JO - Exp Mol Med VL - 48 UR - https://doi.org/10.1038/emm.2015.98 DO - 10.1038/emm.2015.98 ID - Lim2016 ER - TY - JOUR AU - Alfaro, C. AU - Sanmamed, M. F. AU - Rodriguez-Ruiz, M. E. AU - Teijeira, A. AU - Onate, C. AU - Gonzalez, A. AU - Ponz, M. AU - Schalper, K. A. AU - Perez-Gracia, J. L. AU - Melero, I. PY - 2017 DA - 2017// TI - Interleukin-8 in cancer pathogenesis, treatment and follow-up JO - Cancer Treat Rev VL - 60 UR - https://doi.org/10.1016/j.ctrv.2017.08.004 DO - 10.1016/j.ctrv.2017.08.004 ID - Alfaro2017 ER - TY - JOUR AU - Brandmaier, A. AU - Hou, S. Q. AU - Shen, W. H. PY - 2017 DA - 2017// TI - Cell cycle control by PTEN JO - J Mol Biol VL - 429 UR - https://doi.org/10.1016/j.jmb.2017.06.004 DO - 10.1016/j.jmb.2017.06.004 ID - Brandmaier2017 ER - TY - STD TI - Liou AT, Chen MF, Yang CW. Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway.Evid Based Complement Alternat Med. 2017;2017:4063865. ID - ref37 ER - TY - JOUR AU - Cao, J. AU - Zhu, S. AU - Zhou, W. AU - Li, J. AU - Liu, C. AU - Xuan, H. AU - Yan, J. AU - Zheng, L. AU - Zhou, L. AU - Yu, J. AU - Chen, G. AU - Huang, Y. AU - Yu, Z. AU - Feng, L. PY - 2013 DA - 2013// TI - PLZF mediates the PTEN/AKT/FOXO3a signaling in suppression of prostate tumorigenesis JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0077922 DO - 10.1371/journal.pone.0077922 ID - Cao2013 ER - TY - JOUR AU - Arun, R. P. AU - Sivanesan, D. AU - Vidyasekar, P. AU - Verma, R. S. PY - 2017 DA - 2017// TI - PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of colorectal Cancer cells under simulated microgravity JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/s41598-017-06416-4 DO - 10.1038/s41598-017-06416-4 ID - Arun2017 ER - TY - JOUR AU - Qie, S. AU - Diehl, J. A. PY - 2016 DA - 2016// TI - Cyclin D1, cancer progression, and opportunities in cancer treatment JO - J Mol Med (Berl) VL - 94 UR - https://doi.org/10.1007/s00109-016-1475-3 DO - 10.1007/s00109-016-1475-3 ID - Qie2016 ER - TY - JOUR AU - Lv, Z. AU - Rao, P. AU - Li, W. PY - 2015 DA - 2015// TI - MiR-592 represses FOXO3 expression and promotes the proliferation of prostate cancer cells JO - Int J Clin Exp Med VL - 8 ID - Lv2015 ER - TY - JOUR AU - Shrestha, A. AU - Nepal, S. AU - Kim, M. J. AU - Chang, J. H. AU - Kim, S. H. AU - Jeong, G. S. AU - Jeong, C. H. AU - Park, G. H. AU - Jung, S. AU - Lim, J. AU - Cho, E. AU - Lee, S. AU - Park, P. H. PY - 2016 DA - 2016// TI - Critical role of AMPK/FoxO3A Axis in globular adiponectin-induced cell cycle arrest and apoptosis in Cancer cells JO - J Cell Physiol VL - 231 UR - https://doi.org/10.1002/jcp.25080 DO - 10.1002/jcp.25080 ID - Shrestha2016 ER - TY - JOUR AU - Liu, R. AU - Liu, F. AU - Li, L. AU - Sun, M. AU - Chen, K. PY - 2015 DA - 2015// TI - MiR-498 regulated FOXO3 expression and inhibited the proliferation of human ovarian cancer cells JO - Biomed Pharmacother VL - 72 UR - https://doi.org/10.1016/j.biopha.2015.04.005 DO - 10.1016/j.biopha.2015.04.005 ID - Liu2015 ER -