Fig. 4

Knockdown of RAP1A inhibits the growth of CRC cells in vivo. a: Harvested xenografts from nude mice that were subcutaneously injected with SW620 and HT-29 cells. b: the increase of tumor volume in knockdown (KD) group is slower than that in negative control (NC) group. c: the final tumor volumes of KD group are less than that of NC group. d: the final tumor weights of KD group are less than that of NC group. e: the rates of apoptotic tumor cells in the harvested xenografts are higher in KD group than that in NC group. f: the rates of Ki-67 positive tumor cells in the harvested xenografts are lower in KD group than that in NC group. * means p < 0.05. ** means p < 0.01