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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway

Fig. 6

FOXO3 overexpression partly mimics the inhibitory role of RAP1A knockdown in CRC growth. a: FOXO3 expression is higher in overexpression (OE) group than that in negative control (NC) group. b: the relative 490 nm absorbance of OE group increases more slowly than that of NC group within five days. c: upper: FOXO3 overexpression increases G1 phase fraction but decreases S phase fraction in HT-29 cells; lower: FOXO3 overexpression decreases G1 phase fraction but increases G2/M and S phase fraction in SW620 cells. d: the apoptosis rates of OE group are higher than that of NC group. e: the clone numbers of OE group are less than that of NC group. f: the protein expression of CCND1 is increased while no changes of RAP1A and PTEN expression are observed in OE group as compared with NC group. * means p < 0.05. ** means p < 0.01

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