High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway

Table 1 Correlations between RAP1A expression and clinicopathological characteristics in CRC patients

Characteristics	Total	RAP1A expression		P value
Characteristics	Total	Low	High	P value
Gender
Male	60	29	31	0.844
Female	84	42	42	0.844
Age
≤ 60 years	59	24	35	0.084
> 60 years	85	47	38	0.084
Tumor location
Colon	122	62	60	0.392
Rectal	22	9	13	0.392
Tumor size
≤ 5 cm	97	48	49	0.951
> 5 cm	47	23	24	0.951
Tumor differentiation
Well/moderate	110	53	57	0.628
Poor	34	18	16	0.628
Tumor invasion
T1-T2	27	18	9	0.045
T3-T4	117	53	64	0.045
Lymph node metastasis
Absent	70	36	34	0.620
Present	74	35	39	0.620
Serum CEA level
≤ 5 ng/ml	87	46	41	0.290
> 5 ng/ml	57	25	32	0.290

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