Table 2 Univariate analysis for prognostic factors affecting overall survival and disease-free survival
Variables | OS | DFS | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Gender | ||||||
 Male vs. Female | 0.883 | 0.477–1.633 | 0.691 | 1.029 | 0.600–1.767 | 0.916 |
Age | ||||||
  ≤ 60 years vs. > 60 years | 0.755 | 0.408–1.395 | 0.369 | 0.743 | 0.435–1.269 | 0.277 |
Tumor location | ||||||
 Colon vs. Rectal | 1.801 | 0.856–3.791 | 0.121 | 1.870 | 0.983–3.560 | 0.057 |
Tumor size | ||||||
  ≤ 5 cm vs. > 5 cm | 0.849 | 0.425–1.695 | 0.643 | 1.454 | 0.841–2.514 | 0.180 |
Tumor differentiation | ||||||
 Well/moderate vs. Poor | 1.071 | 0.525–2.187 | 0.850 | 1.014 | 0.533–1.929 | 0.967 |
Tumor invasion | ||||||
 T1-T2 vs. T3-T4 | 1.394 | 0.585–3.321 | 0.454 | 1.610 | 0.726–3.567 | 0.241 |
Lymph node metastasis | ||||||
 Absent vs. Present | 2.298 | 1.194–4.424 | 0.013 | 1.759 | 1.016–3.048 | 0.044 |
Serum CEA level | ||||||
  ≤ 5 ng/ml vs. > 5 ng/ml | 1.926 | 1.039–3.572 | 0.038 | 2.635 | 1.523–4.558 | 0.001 |
RAP1A expression | ||||||
 Low vs. High | 2.887 | 1.467–5.681 | 0.002 | 2.396 | 1.356–4.233 | 0.003 |