Table 3 Multivariate analysis for prognostic factors affecting overall survival and disease-free survival
Variables | OS | DFS | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Gender | ||||||
 Male vs. Female | 0.630 | 0.329–1.207 | 0.164 | 0.742 | 0.418–1.318 | 0.309 |
Age | ||||||
  ≤ 60 years vs. > 60 years | 1.159 | 0.590–2.277 | 0.668 | 1.058 | 0.589–1.903 | 0.850 |
Tumor location | ||||||
 Colon vs. Rectal | 1.482 | 0.650–3.382 | 0.350 | 1.765 | 0.862–3.614 | 0.121 |
Tumor size | ||||||
  ≤ 5 cm vs. > 5 cm | 0.813 | 0.393–1.684 | 0.578 | 1.393 | 0.791–2.452 | 0.251 |
Tumor differentiation | ||||||
 Well/moderate vs. Poor | 1.061 | 0.500–2.248 | 0.878 | 0.942 | 0.476–1.866 | 0.865 |
Tumor invasion | ||||||
 T1-T2 vs. T3-T4 | 1.126 | 0.428–2.960 | 0.810 | 1.276 | 0.535–3.048 | 0.583 |
Lymph node metastasis | ||||||
 Absent vs. Present | 2.516 | 1.254–5.050 | 0.009 | 1.863 | 1.037–3.347 | 0.037 |
Serum CEA level | ||||||
  ≤ 5 ng/ml vs. > 5 ng/ml | 1.821 | 0.964–3.439 | 0.065 | 2.412 | 1.372–4.238 | 0.002 |
RAP1A expression | ||||||
 Low vs. High | 2.823 | 1.397–5.707 | 0.004 | 2.149 | 1.189–3.882 | 0.011 |