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Table 3 Multivariate analysis for prognostic factors affecting overall survival and disease-free survival

From: High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway

Variables OS DFS
HR 95% CI P value HR 95% CI P value
Gender
 Male vs. Female 0.630 0.329–1.207 0.164 0.742 0.418–1.318 0.309
Age
  ≤ 60 years vs. > 60 years 1.159 0.590–2.277 0.668 1.058 0.589–1.903 0.850
Tumor location
 Colon vs. Rectal 1.482 0.650–3.382 0.350 1.765 0.862–3.614 0.121
Tumor size
  ≤ 5 cm vs. > 5 cm 0.813 0.393–1.684 0.578 1.393 0.791–2.452 0.251
Tumor differentiation
 Well/moderate vs. Poor 1.061 0.500–2.248 0.878 0.942 0.476–1.866 0.865
Tumor invasion
 T1-T2 vs. T3-T4 1.126 0.428–2.960 0.810 1.276 0.535–3.048 0.583
Lymph node metastasis
 Absent vs. Present 2.516 1.254–5.050 0.009 1.863 1.037–3.347 0.037
Serum CEA level
  ≤ 5 ng/ml vs. > 5 ng/ml 1.821 0.964–3.439 0.065 2.412 1.372–4.238 0.002
RAP1A expression
 Low vs. High 2.823 1.397–5.707 0.004 2.149 1.189–3.882 0.011
  1. Italicized values are less than 0.05