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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Motor neuron and pancreas homeobox 1/HLXB9 promotes sustained proliferation in bladder cancer by upregulating CCNE1/2

Fig. 1

MNX1 is upregulated in bladder cancer tissues and cell lines. a MNX1 mRNA expression levels in TCGA bladder cancer dataset including 19 normal bladder (Nor) and 408 bladder cancer (BLCA) samples. b MNX1 mRNA levels were significantly upregulated in bladder cancer compared to normal bladder tissues by analyzing the GEO dataset (GSE13507), including 10 normal bladder (Nor) and 246 primary bladder cancer (BLCA) tissues. c and d Real-time PCR and western blotting of MNX1 mRNA (c) and protein (d) expression levels, respectively, in bladder cancer tissues (BLCA, T) versus the adjacent noncancerous tissues (N) from eight patients. e and f Real-time PCR and western blotting of MNX1 mRNA (e) and protein (f) expression levels, respectively, in seven human bladder cancer cell lines compared to the immortal SV-HUC-1 bladder cell line. Expression levels were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) or α-tubulin. Bars represent the mean ± SD of three independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001

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