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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Paired box 8 suppresses tumor angiogenesis and metastasis in gastric cancer through repression of FOXM1 via induction of microRNA-612

Fig. 3

PAX8 suppresses EMT and angiogenic activity in gastric cancer cells. a Western blot analysis of E-cadherin (E-cad) and vimentin (Vim) protein levels. b In vitro endothelial cell tube formation assay revealed that conditioned media from PAX8-overexpressing AGS and SGC-7901 cells significantly suppressed formation of tube-like structure by HUVECs. c Real-time PCR analysis of VEGF mRNA levels. d Measurement of VEGF concentrations in conditioned media from PAX8-overexpressing and control AGS and SGC-7901 cells by ELISA. *P < 0.05 vs. vector-transfected cells

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