Fig. 2

LINC01287 inhibition decreased HCC cell proliferation and invasion. a LINC01287 expression in Huh-7 and Bel7402 cells transduced with the control shRNA vector (sh-ctrl) or the LINC01287 shRNA vector (sh-LINC01287). b The MTT assay revealed that LINC01287 down-regulation significantly decreased cell proliferation. c The colony formation assay demonstrated that oncogenic survival was significantly decreased in sh-LINC01287 cells compared with sh-ctrl cells. d A higher frequency of sh-LINC01287 cells were in G1 phase and a lower frequency of these cells were in S phase. e LINC01287 down-regulation affected the expression of G1/S phase checkpoint proteins. f LINC01287 down-regulation decreased the invasion ability of HCC cells, as revealed by the Boyden assay. g The expression levels of MMP-2, MMP-3 and MMP-9 proteins were lower in sh-LINC01287 cells. h The expression level of E-cadherin was increased, while the expression levels of N-cadherin and Vimentin were decreased in sh-LINC01287 cells