Skip to main content


Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Emerging roles of Myc in stem cell biology and novel tumor therapies

Fig. 3

The positive-feedback machinery of N-Myc to induce and maintain the stemness of neuroblastoma. Neuroblastoma is the most common high grade endocrine childhood-onset tumor, which often occurs in the adrenal medulla and sympathetic ganglions. N-Myc exhibits the significant up-regulation in cooperation with NCYM, which is a cis-antisense transcript of oncogene product N-Myc and a functional long non-coding RNA. N-Myc enhances the expression level of Oct4, which play a pivotal role in the maintenance of undifferentiated conditions of medulloblastoma. Oct4 has dual functions; to induce the expression of Nanog, another key transcriptional factor, and to enhance N-Myc expression in a positive-feedback manner [86]. While the filled areas in blue or red indicate opening reading frames (ORFs), the blank areas mean the exons encoding prime untranslated regions such as 3’ and 5’ UTR

Back to article page