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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Emerging roles of Myc in stem cell biology and novel tumor therapies

Fig. 4

The interaction between oncogenic c-Myc and several microRNAs. c-Myc plays a central role in the metabolic reprogramming through the interaction with microRNAs such as miR17-92 cluster, miR23a/b, and miR34a. The association of c-Myc with miR17-92 cluster inhibits phosphatase and tensin homologue deleted on chromosome 10 (PTEN), thereby augmenting the PI3K-Akt-mammalian target of rapamycin (mTOR) axis [112,113,114]. In addition, the interaction of c-Myc with miR23a/b promotes the conversion of glutamine into glutamate with the up-regulation of glutaminase 1 (GLS1) [109,110,111]. Note that while the red arrow indicates “activation,” blue bars indicate “suppression”

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