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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Emerging roles of Myc in stem cell biology and novel tumor therapies

Fig. 6

Scheme of FBW7 structure and the frequency of genetic mutations in gastric cancer patients. a All of the three isoforms of FBW7 are different each other at the N-terminal domain but contain evolutionarily well-conserved interaction domains in the C-terminus (F-box ubiquitin ligase domain and WD40 repeated substrate binding domain). The previous investigation reveals that 7 out of 80 gastric cancer patients (8.8%) had missense mutations in FBW7 gene [191]. Note that red arrows indicate missense mutations. Given the space available, repeated WD40 domains are abbreviated in this Figure. b The Cancer Genome Atlas (TCGA) information provided by the cBio Cancer Genomics Portal at Memorial Sloane Kettering Cancer Center ( shows that more than 15% of patients of both uterine carcinoma and colorectal adenocarcinoma harbor the mutation of FBW7 gene

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