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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Regorafenib suppresses colon tumorigenesis and the generation of drug resistant cancer stem-like cells via modulation of miR-34a associated signaling

Fig. 3

Regorefenib suppresses stemness phenotypes in DLD-1R cells. Regorefenib treatment significantly suppressed colony formation (a), tumor sphere formation (b) and the percentage of SP cells in DLD-1R and HCT-116R cells (c). d Western blot analysis shows the decreased protein expression of stemness (WNT1, Notch1) and oncogenic (phosphorylated form of mTOR, STAT3 and vimentin) markers while an increased level of the pro-apoptotic markers, Bax and PARP (cleaved PARP). *p < 0.05

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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