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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation

Fig. 7

Proposed model of PCBP1 stabilizing p27 mRNA to repress cell transformation and carcinogenesis. PCBP1 binds to p27 mRNA 3'-UTR region via 5'-AUUAAGUAAU-3' to stabilize mRNA against degradation, while enhance the translation, resulting in more p27 protein that participates in cell cycle surveillance to maintain cell homeostasis and to inhibit carcinogenesis, while p27 degradation by ubiquitin ligase Skp2 promotes cell cycle progression after the proper surveillance. In tumor tissues, anti-cancer drugs can induce p27 expression to induce tumor cell cycle arrest and apoptosis. Loss of PCBP1 expression would expose p27 mRNA for degradation, leading to lower expression of p27 protein and unregulated cell proliferation, eventually hyperplasia and carcinogenesis, which are independent of Skp2 status

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