Fig. 2

Statistical analysis of SWATH data. a Histogram shows the distribution of coefficients of variation (CVs) among technical and biological replicates of Ctrl-K562 and Curcu-K562 cells. More than 90% of the proteins as highlighted by the shadow have CV ≤ 25%. b Volcano plot of 1796 quantified proteins illustrating expression increases and decreases following curcumin treatment. Red dots correspond to proteins showing a fold change (FC) ≥ ±1.5 in relative abundance and a corrected BY p-value < 0.05 (values indicated by vertical and horizontal dashed lines) and considered significantly differentially modulated in untreated and curcumin-treated K562 cells. c Heat map analysis of 377 modulated proteins among technical and biological replicates of Ctrl-K562 and Curcu-K562 cells. The value of the MS signal intensity is shown