Fig. 7

Curcumin induces a miR-22-mediated enhancement of anti-proliferative effects of imatinib. Cell viability assay (MTT assay) of K562 cells treated as indicated for 24 h, shows that curcumin induced a miR-22-mediated sensitization to imatinib. The reported values are the mean of three independent experiments; statistical significance was calculated as specified by lines: *p < 0.05, **p < 0.01. The table reports in detail the values of the histogram. Ctrl: cells in DMSO or with increasing doses of only imatinib; IM: imatinib