Fig. 8

The proposed model of miR-22/IPO7/HIF-1a axis modulation induced by curcumin in CML. a In basal condition CML cells are characterized by an efficient HIF-1α activity responsible of active transcription of several target genes some of which associated to glycolytic metabolism. b Curcumin by inducing up-regulation of miR-22 elicits the inhibition of IPO7 expression, hindering the HIF-1α translocation and causing the global down-regulation of glycolytic enzymes as highlighted by our quantitative proteomic data. NCP: Nuclear Pore Complex