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Table 4 Proteins implicated in nuclear import/export identified by MS in K562cells

From: SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis

UniProt Accession Number UniProt Entry Name Gene Name Protein Name Fold Change (Curcu-K562 vs Ctrl K562) p-Value BY-Pvalue
O00410 IPO5_HUMAN IPO5 Importin-5 -1.530 0.002162 0.0383
O95373 IPO7_HUMAN IPO7 Importin-7 -2.332 0.000107 0.0030
Q96P70 IPO9_HUMAN IPO9 Importin-9 −2.241 0.121934 > 0.999
P52292 IMA1_HUMAN KPNA2 Importin subunit alpha-1 −1.040 0.040815 0.5065
O00629 IMA3_HUMAN KPNA4 Importin subunit alpha-3 −1.279 0.002692 0.0465
O00505 IMA4_HUMAN KPNA3 Importin subunit alpha-4 −1.667 0.086100 0.9772
Q14974 IMB1_HUMAN KPNB1 Importin subunit beta-1 −1.114 0.000088 0.0026
Q92973 TNPO1_HUMAN TNPO1 Transportin-1 −1.801 0.00045 0.0099
E9PFH4 E9PFH4_HUMAN TNPO3 Transportin-3 −1.875 0.221323 > 0.999
O14980 XPO1_HUMAN XPO1 Exportin-1 −1.804 0.000086 0.0026
P55060 XPO2_HUMAN CSE1L Exportin-2 −1.530 0.011327 0.1659
Q9HAV4 XPO5_HUMAN XPO5 Exportin-5 −1.698 0.000021 0.0008
P12270 TPR_HUMAN TPR Nucleoprotein TPR −1.121 0.001823 0.0330
Q9UKX7 NUP50_HUMAN NUP50 Nuclear pore complex protein Nup50 1.334 0.246 > 0.999
  1. Proteins considered significantly modulated by curcumin treatment (Fold Change ≥1.5 and BY-Pvalue ≤10−5) are in bold