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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Isoliquiritigenin suppresses human melanoma growth by targeting miR-301b/LRIG1 signaling

Fig. 4

MiR-301b mitigated the ISL induced tumor cell apoptosis. A375 and A2058 cells were transfected with miR-301b or control(NC) (a-d) Representative images and quantification of TUNEL staining of A375 and A2058 cells after being treated with ISL (0,15 μM) and ISL (0,10 μM) respectively. e-h Flow cytometry analysis of apoptosis of A375 and A2058 cells after being treated with ISL (0, 15 μM) and ISL (0, 10 μM) for 24 h respectively. i, j Expression of apoptosis associated proteins (c-PARP, Bax, bcl-2, C-caspase-3) of A375 and A2058 cells after being treated with ISL (0, 15 μM) and ISL(0, 10 μM) for 24 h respectively. *P < 0.05, **P < 0.01, n = 3

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