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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA

Fig. 3

lncRNA PART1 is essential for gefitinib resistance of ESCC cells. a The silencing efficacy was evaluated by RT-qPCR after transfection of three siRNAs of PART1. **P < 0.01, ***P < 0.001 compared to si-NC group. b Knockdown of PART1 promoted apoptosis induced by gefitinib treatment in both gefitinib-resistant cell lines. *P < 0.05 compared to si-NC group. c The IC50 value of trastuzumab was detected for both sensitive and resistant cells by CCK8 assay. *P < 0.05 compared to si-NC group. d Colony formation assay analysis of anchorage-independent growth. *P < 0.05, **P < 0.01 compared to si-NC group. e Flow cytometry analysis of cell apoptosis caused by knockdown of lncRNA PART1. *P < 0.05 compared to si-NC group

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