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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: WIPF1 antagonizes the tumor suppressive effect of miR-141/200c and is associated with poor survival in patients with PDAC

Fig. 3

Effect of miR-141 and miR-200c on PDAC cell growth. a PANC-1 and BxPC3 cells were stably infected with empty vector as control (Vec) or lentivirus carrying miR-141 or miR-200c and cell proliferation was measured. b PANC-1 and BxPC3 cells were stably infected with empty vector or lentivirus carrying anti-miR-141 or anti-miR-200c and cell proliferation was measured. Data represent the mean +/− SD of three independent experiments. * P < 0.05. c-d miR-141 but not miR-200c suppresses PDAC tumor growth in the xenograft model. PANC-1 (c) or BxPC-3 (d) cells were infected with empty vector or lentivirus carrying miR-141 or miR-200c and the transfected cells (1 × 107) were injected subcutaneously into the athymic nude mice. Mice were sacrificed 28 days after the injection. Each group contained 5 animals. Tumor volume and weight were measured. * P < 0.05

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