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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: RBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma

Fig. 4

RBM38 induced apoptosis and senescence of human liver cancer cells. a Apoptosis was assessed using flow cytometry. The bar graph on the right presents the percentage of apoptotic cells. Representative quadrant figures are presented on the left. The results shown are representative of three independent experiments. b Cells were stained with the senescence marker β-galactosidase. The blue staining around the nucleus in SMMC7721-RBM38-OE and HepG2-RBM38-OE cells indicates cellular senescence. c Cell cycle progression was measured using flow cytometry. The progression of SMMC7721-RBM38-OE and HepG2-RBM38-OE cells was delayed G1 phase and a shortened S phase compared to control cells, respectively. Representative photographs and quantification are shown

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